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Palmitoyl pentapeptide (exact variant required)
The burned-in captions and transcript carry the scientific claims and their limitations. The visuals are conceptual illustrations, not validated molecular models or experimental images. The video has no voice or audio. The full explanation is visible on screen; optional accessible captions are available in the player.
Read every result in its study context. A cell experiment, animal model, exploratory analysis and controlled human trial answer different questions.
Prepared 05 November 2026. Regulatory status is jurisdiction- and date-specific. No claim of specialist review or exhaustive evidence coverage.
Transcript
Studied material: pal-KTTKS
Palmitoyl pentapeptide is an incomplete identity unless the exact sequence is specified. One published cosmetic trial tested pal-KTTKS, a defined five-amino-acid sequence with a lipid attachment. [1]
HUMAN TRIAL | Split-face comparison
Ninety-three women participated in a twelve-week, randomized, double-blind split-face study. Researchers compared a moisturizer containing pal-KTTKS with the same moisturizer without it. [1]
Evidence for a specific formulation
The tested formulation improved fine-line and wrinkle measurements relative to the control. The evidence concerns that sequence, vehicle, study population and period of observation. [1]
Match sequence, vehicle and outcome
It does not establish identical effects for every palmitoylated peptide or finished serum. Matching the ingredient and formulation is essential before transferring a claim. [1]
Sources and context
These linked sources support the evidence distinctions in this short overview. This is not a systematic review, endorsement or treatment recommendation.
- Robinson et al. (2005): Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin →Pal-KTTKS in a moisturizer; 93 women, twelve weeks; fine-line and wrinkle endpoints.
