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5-Amino-1MQ
The burned-in captions and transcript carry the scientific claims and their limitations. The visuals are conceptual illustrations, not validated molecular models or experimental images. The video has no voice or audio. The full explanation is visible on screen; optional accessible captions are available in the player.
Read every result in its study context. A cell experiment, animal model, exploratory analysis and controlled human trial answer different questions.
Prepared 05 November 2026. Regulatory status is jurisdiction- and date-specific. No claim of specialist review or exhaustive evidence coverage.
Transcript
5-Amino-1MQ | Small molecule
5-Amino-1MQ is a small-molecule research inhibitor of NNMT, an enzyme involved in nicotinamide metabolism. It is not a peptide, despite frequent grouping with peptides. [1]
CELL AND MOUSE RESEARCH
Researchers studied related compounds in laboratory assays and fat cells, then tested 5-Amino-1MQ in mice with obesity induced by a high-fat diet. [1]
Measured in mice: weight and fat mass
The short mouse experiment reported lower body weight and fat mass without a measured reduction in food intake. These findings support further investigation. [1]
Human benefit and safety need direct evidence
They do not establish effective weight management in people. Human exposure, patient-important outcomes and longer-term safety require direct testing of the exact compound. [1]
Sources and context
These linked sources support the evidence distinctions in this short overview. This is not a systematic review, endorsement or treatment recommendation.
- Neelakantan et al. (2018): Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice →NNMT inhibition, molecular identity and an eleven-day 5-amino-1MQ experiment in male mice.
