Visual summary only. The research findings, limitations and references accompany the card on this page.
The chemical drawing shows source-verified two-dimensional connectivity and stereochemistry, not an experimental three-dimensional conformation. The biological setting is an illustration. Original study diagrams summarize cited research without reproducing publication artwork or inventing quantitative results.
Argireline / acetyl hexapeptide-8
SNARE-complex research
All-L N-acetyl hexapeptide with C-terminal argininamide; parent, no acetate counterion- Molecular formula
- C34H60N14O12S
- Molecular weight
- 889.0 g/mol
- Class
- Cosmetic hexapeptide
- Identity
- Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2
Research snapshot
Argireline is a SNAP-25-inspired cosmetic peptide. Laboratory work examined vesicle-release machinery, and small topical studies reported mixed wrinkle outcomes. Its topical performance is formulation-dependent and not equivalent to botulinum toxin treatment.
Laboratory + small cosmetic trials
Identity & representation
Reference parent, not an AXON formulation or salt.
Educational reference only. Not a dosing guide, treatment recommendation or product endorsement.
Acetyl hexapeptide-8 · Ac–Glu–Glu–Met–Gln–Arg–Arg–NH2[1]
View the chemical structure →Sources checked: 2026-11-06. Identity and evidence limits are stated above. Independent specialist review is pending.
What researchers study
Argireline is a SNAP-25-inspired cosmetic peptide. Laboratory work examined vesicle-release machinery, and small topical studies reported mixed wrinkle outcomes. Its topical performance is formulation-dependent and not equivalent to botulinum toxin treatment.
Vesicle-release assays
Periorbital wrinkle measurements
Skin-formulation performance
Mechanism in context
- SNAP-25-inspired sequence is studied
- SNARE assembly / stability is perturbed in assays
- Neurotransmitter-release readouts change
Cell-assay mechanisms do not prove penetration to facial motor nerves in intact human skin. Cosmetic clinical endpoints and formulation effects must remain separate.
Simplified publication-grounded schematic, not a solved protein structure or proof of clinical benefit.
Selected evidence
Laboratory + small cosmetic trials
The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study.[3]
Randomized placebo-controlled cosmetic study · 60 subjects; 3:1 allocation · 4 weeks
Observed: Periorbital wrinkle assessments favored the peptide formulation.
Periorbital wrinkle assessments favored the peptide formulation. Small short-term cosmetic trial; does not establish toxin-equivalent efficacy.
Limit: Small short-term cosmetic trial; does not establish toxin-equivalent efficacy.
Investigating the effects of Argireline in a skin serum containing hyaluronic acids on skin surface wrinkles using the Visia® Complexion Analysis camera system for objective skin analysis.[4]
Double-blind split-face formulation comparison · 19 women · 4 weeks
Observed: Adding Argireline to a hyaluronic-acid serum did not significantly improve wrinkle scores versus the matching side.
Adding Argireline to a hyaluronic-acid serum did not significantly improve wrinkle scores versus the matching side. Small sample and formulation-specific result.
Limit: Small sample and formulation-specific result.
Reference identity in detail
Sequences and form distinctions describe the cited reference substance, not a verified supplier preparation.
Research scope
Targeted source verification, not a systematic review. Citation quality and molecule-specific applicability are stated separately.
Safety & evidence limits
Cosmetic trials are small and short, with mixed results across formulations and measurement systems.
A 19-person split-face study found no significant incremental effect from adding Argireline.
Do not label it a toxin-equivalent treatment or infer injection safety from cosmetic studies.
Practical identity notes
- All-L N-acetyl hexapeptide with C-terminal argininamide; parent, no acetate counterion
- No original PubChem 3D conformer was available for this exact reference in the checked endpoint; use exact 2D structure.
- Reference identity is not confirmation of product contents, purity, sterility or therapeutic equivalence.
- Reject PubChem71587772: its graph has a carbonyl replaced by =CH2 and is not Ac-EEMQRR-NH2. CID11228338 name may say acetate, but the accepted graph contains no counterion.
The 10-second takeaway
A defined cosmetic hexapeptide with laboratory mechanisms and mixed short-term clinical evidence.
What the visual panels show
Original diagrams summarize the cited research or documented evidence search. They are not copied publication figures or claims of treatment benefit.
MECHANISM / STUDY CONTEXT[2]
Publication-grounded mechanism schematic · Original publication-grounded diagram
SNAP-25-inspired sequence · SNARE assembly examined in laboratory assays · Neurotransmitter-release readouts change
Interpretation: Cell-assay mechanisms do not prove penetration to facial motor nerves in intact human skin. Cosmetic clinical endpoints and formulation effects must remain separate.
Vesicle-release experiments[2]
LABORATORY ASSAYS · Original publication-grounded diagram
SNARE assembly / stability perturbed in assays
Does not demonstrate access to facial motor nerves through intact skin.
Interpretation: Does not demonstrate access to facial motor nerves through intact skin. Original conceptual illustration only; no fabricated data, docking geometry or clinical extrapolation.
Short cosmetic trial[3]
HUMAN CONTROLLED STUDY · Original publication-grounded diagram
Wrinkle assessments favored peptide formulation
60 subjects; 4 weeks; not toxin-equivalent efficacy.
Interpretation: 60 subjects; 4 weeks; not toxin-equivalent efficacy. Original conceptual illustration only; no fabricated data, docking geometry or clinical extrapolation.
No significant added effect[4]
HUMAN SPLIT-FACE STUDY · Original publication-grounded diagram
No significant added wrinkle-score improvement
19 women; 4 weeks; hyaluronic-acid serum comparison.
Interpretation: 19 women; 4 weeks; hyaluronic-acid serum comparison. Original conceptual illustration only; no fabricated data, docking geometry or clinical extrapolation.
Follow the evidence
Sources & what they support
- PubChem CID 11228338: source reference graph
Supports: Exact reference graph, stereochemistry, formula and mass
Original structure record · Download source SDF
Original PubChem 2D source structure record.
- A synthetic hexapeptide (Argireline) with antiwrinkle activity.
Supports: Exact Ac-EEMQRR-NH2 sequence and SNARE assay work
- The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study.
Supports: 60-subject randomized cosmetic trial
- Investigating the effects of Argireline in a skin serum containing hyaluronic acids on skin surface wrinkles using the Visia® Complexion Analysis camera system for objective skin analysis.
Supports: 19-subject null split-face study
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