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Ibutamoren, also called MK-677, is a non-peptide compound that mimics ghrelin signaling.

2
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Research has examined its effects on growth hormone and body composition.

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A randomized trial in healthy older adults found increased growth hormone and fat-free mass.

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However, increased mass did not translate into improved strength or function.

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The study also reported increased fasting glucose and reduced insulin sensitivity.

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Appetite, swelling and muscle discomfort were among the observed issues that complicate the picture.

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Body-composition measurements are useful, but they are only part of the assessment.

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Durable functional benefits and harms need to be evaluated together.