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NAD+ is a coenzyme involved in cellular energy reactions.

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Its essential biological role does not, by itself, establish benefits from adding more.

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A 2019 pilot study assigned eleven men to NAD+ or saline and tracked blood and urine chemistry around a

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six-hour research infusion.

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Researchers observed changes in NAD+ and related metabolites.

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That answers questions about what happens to the compound, rather than whether people live longer.

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The study was small and brief. It cannot establish lasting improvements in energy, cognition or aging, or

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reliably detect uncommon and delayed harms.