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Humanin was identified during a search for factors that protected cells from Alzheimer-related laboratory

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insults. That discovery opened a new research direction.

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Later work examined interactions with Bax, a protein involved in programmed cell death.

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Humanin is also linked to a short sequence within mitochondrial DNA.

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The biology is more complicated than a mitochondrial anti-ageing switch.

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Related nuclear sequences and the source of the peptide have also been investigated.

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Protecting cultured cells does not demonstrate prevention of dementia or longer human life.

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Keep humanin’s experimental promise separate from clinical claims that require direct testing in people.